医院名:自由が丘消化器・内視鏡クリニック 
住所:〒152-0035 東京都目黒区自由が丘2丁目9−6 Luz自由が丘5階 
電話番号:03-6421-2852

医療情報

2019.03.20

除菌後胃癌③(胃内視鏡/胃カメラ)

除菌後胃癌に関して、院長が筆頭著者である論文 “Incidence of metachronous gastric cancer in patients whose primary gastric neoplasms were discovered after Helicobacter pylori eradication”が、GIE誌(impact factor 7.204)に掲載されます。

要旨は以下になります。次回、内容をご説明致します。

BACKGROUND AND AIMS:

The incidence of metachronous gastric cancer (MGC) in patients whose primary gastric neoplasm is discovered after Helicobacter pylori (H pylori) eradication remains unclear. Here, we evaluated the long-term effect of previous H pylori eradication on development of MGC after endoscopic submucosal dissection (ESD).

METHODS:

We analyzed prospectively collected data of consecutive patients with successful H pylori eradication more than 1 year before (eradicated group; 180 patients), or after (control group; 602 patients) initial curative endoscopic submucosal dissection (ESD). These patients were also followed by endoscopy for over 2 years. Propensity score matching and inverse probability of treatment weighting (IPTW) were used in order to adjust for confounding variables during data analysis. The main outcome was the incidence of MGC after initial ESD.

RESULTS:

In a propensity-matched analysis of 174 pairs, the incidence of MGC was similar in the two cohorts (33.9 per 1,000 person-years vs 40.8 per 1,000 person-years in the control group, P = 0.454) at a median follow-up of 4.1 years (IQR, 3.0-5.6 years). Incidences were also similar in the 2 groups when data were analyzed using IPTW, even after exclusion of 123 patients with successful H pylori eradication <5 years before initial ESD. Multiple Cox regression analysis revealed age, differentiated-type histology and initial multiplicity were predictors of MGC in patients after initial curative ESD.

CONCLUSIONS:

The frequency of follow-up surveillance after initial curative ESD should be kept constant, irrespective of whether H pylori eradication is performed before or after initial curative ESD.

目黒区、世田谷区、大田区、川崎市の胃内視鏡(胃カメラ)、大腸内視鏡(大腸カメラ)なら
自由が丘消化器・内視鏡クリニック
〒152-0035 東京都目黒区自由が丘2丁目9−6 Luz自由が丘5階 電話番号:03-6421-2852

院長 岡田 和久

内視鏡専用24時間WEB予約 初診受付専用24時間WEB予約
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内視鏡専用24時間WEB予約 初診受付専用24時間WEB予約